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Use of intragastric pH monitoring in gastroesophageal reflux disease.

Katz PO

Division of Gastroenterology, Albert Einstein Medical Center, 5501 Old York Road, Klein Building, Suite 331, Philadelphia, PA 19141, USA. katzp@einstein.edu

Prolonged intragastric pH monitoring is a valuable technique for evaluating head-to-head comparisons of the antisecretory effects of different pharmacologic agents, for studying the effects of higher doses of proton pump inhibitors (PPIs) on daytime and nighttime pH control, for evaluating the effects of dose timing in relation to a meal on the intragastric pH response to these antisecretory agents, and for examining interindividual variability in individual pH response to PPIs taken orally. Measuring intragastric pH has helped immeasurably in understanding the efficacy of PPIs and is especially useful in the clinical arena to guide the management of patients across the spectrum of gastroesophageal reflux disease.

Published 21 February 2005 in Gastrointest Endosc Clin N Am, 15(2): 277-87.
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